A microfluidic platform for probing small artery structure and function
نویسندگان
چکیده
منابع مشابه
A microfluidic platform for probing small artery structure and function.
Although pathologic changes to the structure and function of small blood vessels are hallmarks of various cardiovascular diseases, limitations of conventional investigation methods (i.e. pressure myography) have prohibited a comprehensive understanding of the underlying mechanisms. We developed a microfluidic device to facilitate assessment of resistance artery structure and function under phys...
متن کاملSmall artery structure and function in hypertension
It has been known for some considerable time that sustained hypertension changes the circulatory architecture both in the heart and blood vessels. The histopathological alterations are of considerable interest because once they have developed they appear to carry an adverse prognostic risk. In the heart it is apparent that there is hypertrophy. This extends also to the large- and medium-sized b...
متن کاملArtery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function.
We present a compact microfluidic platform for the automated, multimodal assessment of intact small blood vessels. Mouse olfactory artery segments were reversibly loaded onto a microfluidic device and kept under physiological (i.e., close to in vivo) environmental conditions. For immunohistochemical endpoint protein analysis, automated on chip fixation and staining of the artery eliminated the ...
متن کاملDevelopment of a Microfluidic Platform to Investigate Effect of Dissolved Gases on Small Blood Vessel Function
In this thesis I present a microfluidic platform developed to control dissolved gases and monitor dissolved oxygen concentrations within the microenvironment of isolated small blood vessels. Dissolved gas concentrations are controlled via permeation through the device substrate material using a 3D network of gas and liquid channels. Dissolved oxygen concentrations are measured on-chip via fluor...
متن کاملA microfluidic platform for probing single cell plasma membranes using optically trapped Smart Droplet Microtools (SDMs).
We recently introduced a novel platform based upon optically trapped lipid coated oil droplets (Smart Droplet Microtools-SDMs) that were able to form membrane tethers upon fusion with the plasma membrane of single cells. Material transfer from the plasma membrane to the droplet via the tether was seen to occur. Here we present a customised version of the SDM approach based upon detergent coated...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Lab on a Chip
سال: 2010
ISSN: 1473-0197,1473-0189
DOI: 10.1039/c004675b